About GeneSoC®

 Polymerase chain reaction (PCR) is a nucleic acid amplification method that was developed in 1980’s and have been widely used in molecular biology because of its high sensitivity. However, there was a problem that it was difficult to use it for Point of Care Testing (POCT) at medical institutions etc. as a larger device and a longer time are required due to thermal cycling.
 With the anthrax incident occurring in the United States in 2001, National Institute of Advanced Industrial Science and Technology (AIST) in Japan started research on new “rapid” and “minimized” PCR technology. This research was handed over by jTAS Inc., a startup company originating from AIST, and GeneSoC® was developed using the microfluidic thermal cycling technology.

 In the treatment of infectious diseases, antimicrobial stewardship is being promoted as a response to international antimicrobial resistance (AMR). Under these circumstances, the ability of GeneSoC® to rapidly, accurately and conveniently identify the causative microorganisms will contribute to assistance for diagnosis of infectious diseases and also antimicrobial stewardship by POCT. Kyorin will continuously expand GeneSoC® to medical and other fields.

 The core technology of GeneSoC® is the microfluidic thermal cycling technology.
In GeneSoC®, a small volume of reaction mixture repeatedly moves between two temperature zones in a short microchannel for thermal cycling using microblowers. In a conventional thermal cycle system, a large metal block attached Peltier devices and cooling fins are required to change the temperature of reaction mixture and it takes time to change the temperature of the metal block due to the large thermal capacitance.
 With our technology, nucleic acid amplification occurs faster, with a more compact instrument, and less power consumption.

 GeneSoC® is a genetic measurement device in which a fluorescently labeled probe is used to conduct real-time detection of nucleic acid amplification based on the microfluidic thermal cycling technology. It consists of Main Unit and Detection Unit.
 Up to 4 Detection Units can be added and the simultaneous test of multiple samples is possible.
 In addition, because Detection Unit is independently controlled, another test can be conducted during the measurement by using another unit.